Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.71 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246533 | 0.95 | ACHE (0.78) | ACHEEPHX1 | |
| SCHEMBL9812806 | 0.93 | ACHE (0.81) | ACHEEPHX1 | |
| SCHEMBL5244780 | 0.91 | ACHE (0.86) | ACHEEPHX1EPHX2 | |
| SCHEMBL20588996 | 0.91 | ACHE (0.79) | ACHEEPHX1EPHX2 | |
| SCHEMBL5247986 | 0.89 | ACHE (0.82) | ACHEEPHX1EPHX2 | |
| SCHEMBL13660365 | 0.89 | ACHE (0.65) | ACHEEPHX1EPHX2 | |
| SCHEMBL20580780 | 0.87 | ACHE (0.79) | ACHEEPHX1EPHX2 | |
| SCHEMBL6289600 | 0.87 | ACHE (0.79) | ACHEEPHX1EPHX2 | |
| SCHEMBL13700167 | 0.87 | ACHE (0.84) | ACHEEPHX1EPHX2 | |
| SCHEMBL6289704 | 0.86 | ACHE (0.63) | ACHEEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057894-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE AND POLYCYSTIC LIVER DISEASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-04-23 | — | — | WO | disclosed |
| US-20150105361-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE AND POLYCYSTIC LIVER DISEASE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105361-A1 | METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE AND POLYCYSTIC LIVER DISEASE | PKD1, PKD2, GLS | ACHE 4884/4885EPHX1 3481/4885EPHX2 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.