Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632865 | 0.83 | PIK3CG (0.45) | PIK3CGMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL2380472 | 0.81 | PIK3CG (0.53) | PIK3CGMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL7125440 | 0.80 | SREBF2 (0.58) | SREBF2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL16640659 | 0.78 | MAPT (0.52) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL7121746 | 0.78 | HDAC3 (0.63) | SREBF2HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL3244009 | 0.78 | MAPKAPK2 (0.39) | LCKCA12CA1CA9MAP4K4 | |
| SCHEMBL25620110 | 0.76 | CA12 (0.48) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL16302366 | 0.74 | CA12 (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL3237383 | 0.73 | MAPKAPK2 (0.38) | LCKCA12CA1CA9MAPKAPK2 | |
| SCHEMBL10305747 | 0.73 | MAP4K4 (0.46) | HDAC3HDAC1HDAC2HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | SREBF2 1397/4885HDAC3 151/4885HDAC1 94/4885 |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | SREBF2 1397/4885HDAC3 151/4885HDAC1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.