Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.62 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7125440 | 0.85 | SREBF2 (0.58) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL3140270 | 0.82 | SMN1; SMN2 (0.65) | HDAC3HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL23714788 | 0.79 | HRH2 (0.50) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL3786374 | 0.78 | CYP17A1 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL16640661 | 0.78 | SREBF2 (0.41) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL7874987 | 0.77 | ALDH1A1 (0.53) | HDAC3HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL3789848 | 0.77 | CYP17A1 (0.62) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL31671045 | 0.77 | CYP17A1 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL26666910 | 0.77 | CYP17A1 (0.76) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL25362033 | 0.77 | ALDH1A1 (0.51) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1440383-A | PPAR gamma modulators | SANKYO CO (JP) | 2003-09-03 | — | — | CN | disclosed |
| US-20030134859-A1 | PPAR-gamma modulator | SANKYO COMPANY, LIMITED (JP) | 2003-07-17 | — | — | US | disclosed |
| EP-1277729-A1 | PPAR (GAMMA) MODULATORS | Sankyo Company, Limited (JP) | 2003-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134859-A1 | PPAR-gamma modulator | PPARG, PPARA, PPARD | HDAC3 365/4885HDAC1 917/4885HDAC2 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.