Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 5/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244009 | 0.86 | MAPKAPK2 (0.39) | MAPKAPK2CA12CA1CA9LCK | |
| SCHEMBL14250685 | 0.74 | MAPKAPK2 (0.44) | MAPKAPK2CA12CA1CA9NAMPT | |
| SCHEMBL16640661 | 0.73 | SREBF2 (0.41) | MAPKAPK2CA12CA1CA9LCK | |
| SCHEMBL1368674 | 0.73 | S1PR2 (0.58) | MAPKAPK2CA12CA1CA9LCK | |
| SCHEMBL16302366 | 0.73 | CA12 (0.51) | CA12CA1CA9LCKNAMPT | |
| SCHEMBL12902766 | 0.71 | ATR (0.45) | MAPKAPK2CA12CA1CA9LCK | |
| SCHEMBL5879121 | 0.71 | L3MBTL1 (0.47) | CA12CA1CA9CYP17A1ATR | |
| SCHEMBL3786493 | 0.71 | L3MBTL1 (0.44) | CA12CA1CA9NAMPTCYP17A1 | |
| SCHEMBL9909940 | 0.71 | S1PR2 (0.47) | MAPKAPK2CA12CA1CA9LCK | |
| SCHEMBL14439972 | 0.70 | CA12 (0.49) | CA12CA1CA9LCKNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |