Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664296 | 0.95 | RAB9A (0.51) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664007 | 0.95 | RAB9A (0.51) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1665170 | 0.85 | NPC1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664627 | 0.84 | NPC1 (0.47) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664925 | 0.84 | SLC2A1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1665171 | 0.84 | SLC2A1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664625 | 0.84 | RAB9A (0.48) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664923 | 0.84 | NPC1 (0.46) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6126242 | 0.83 | NPC1 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1664481 | 0.82 | SMN1; SMN2 (0.45) | NPC1RAB9ACYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |