Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770073 | 0.95 | HRH3 (0.52) | HRH3ALDH1A1MAPTGFERCFTR | |
| SCHEMBL1664936 | 0.95 | HRH3 (0.52) | HRH3ALDH1A1MAPTGFERCFTR | |
| SCHEMBL1664934 | 0.95 | HRH3 (0.55) | HRH3ALDH1A1MAPTGFERCFTR | |
| SCHEMBL1664061 | 0.87 | DHPS (0.50) | ALDH1A1MAPTGFERRAB9AMEN1 | |
| SCHEMBL8770716 | 0.82 | DHPS (0.53) | ALDH1A1MAPTGFERROCK1RAB9A | |
| SCHEMBL1664064 | 0.80 | RAB9A (0.40) | ALDH1A1MAPTGFERRAB9AMEN1 | |
| SCHEMBL1664358 | 0.79 | NPC1 (0.46) | MAPTGFERRAB9AMEN1KMT2A | |
| SCHEMBL1664961 | 0.79 | NPC1 (0.65) | MAPTGFERRAB9AMEN1KMT2A | |
| SCHEMBL1664469 | 0.78 | RAB9A (0.58) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL8769706 | 0.78 | RAB9A (0.58) | ALDH1A1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |