Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8738722 | 0.87 | HDAC3 (0.63) | HDAC1HDAC3HDAC2HDAC6RAB9A | |
| SCHEMBL16644349 | 0.84 | HDAC6 (0.53) | HDAC1HDAC3HDAC2HDAC6OPRM1 | |
| SCHEMBL16632207 | 0.81 | HDAC3 (0.55) | HDAC1HDAC3HDAC2HDAC6OPRM1 | |
| SCHEMBL16644394 | 0.77 | ATM (0.46) | HDAC1HDAC3HDAC2HDAC6MAPT | |
| SCHEMBL17830863 | 0.75 | HDAC1 (0.44) | HDAC1HDAC3HDAC2HDAC6RAB9A | |
| SCHEMBL12939730 | 0.73 | PTGER4 (0.46) | RAB9AVNN1 | |
| SCHEMBL16626820 | 0.73 | VNN1 (0.64) | HDAC1HDAC3HDAC2HDAC6VNN1 | |
| SCHEMBL19779315 | 0.73 | VNN1 (0.59) | VNN1 | |
| SCHEMBL16644393 | 0.73 | HDAC1 (0.72) | HDAC1HDAC3HDAC2HDAC6KDM4E | |
| SCHEMBL18742543 | 0.72 | HDAC3 (0.61) | HDAC1HDAC3HDAC2HDAC6VNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055299-B1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS INC (US) | 2021-01-06 | — | — | EP | disclosed |
| US-20160279128-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. | 2016-09-29 | — | — | US | disclosed |
| US-9278963-B2 | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors | ACETYLON PHARMACEUTICALS, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| WO-2015054474-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20150105384-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279128-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC3 11/4885HDAC2 3/4885 |
| US-20150105384-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC2 | HDAC1 1/4885HDAC3 11/4885HDAC2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.