Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24606816 | 0.82 | TSHR (0.50) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5986980 | 0.78 | TSHR (0.53) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL16639870 | 0.78 | USP2 (0.49) | TSHRL3MBTL1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL16825967 | 0.76 | GAA (0.47) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL25633233 | 0.76 | PIK3CD (0.42) | TSHRALDH1A1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL21138360 | 0.76 | TSHR (0.55) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7601879 | 0.76 | TSHR (0.55) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1140258 | 0.75 | ALDH1A1 (0.49) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL24587358 | 0.75 | L3MBTL1 (0.42) | GAATSHRL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL17173125 | 0.75 | L3MBTL1 (0.42) | GAATSHRL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015054474-A1 | PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | WO | disclosed |