Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664492 | 0.94 | NPC1 (0.66) | NPC1RAB9AESR1MAPK10MAPK8 | |
| SCHEMBL1665773 | 0.91 | MAOB (0.56) | NPC1RAB9AMAPK10MAOBMAOA | |
| SCHEMBL1665219 | 0.86 | MAPK10 (0.43) | NPC1RAB9AMAPK10MAPK8MAOB | |
| SCHEMBL1665249 | 0.84 | SMO (0.54) | MAPK10MAPK8MAOBSMOMAPK13 | |
| SCHEMBL1665007 | 0.83 | MAOB (0.48) | NPC1RAB9AMAOBMAOAABL1 | |
| SCHEMBL1665395 | 0.83 | SMO (0.51) | MAPK10MAPK8MAOBSMOMAPT | |
| SCHEMBL1665429 | 0.83 | ESR1 (0.52) | NPC1RAB9AESR1MAPK10MAPK8 | |
| SCHEMBL1665083 | 0.82 | SMO (0.52) | MAPK10MAPK8MAOBSMONR3C1 | |
| SCHEMBL1665738 | 0.81 | MAOB (0.46) | NPC1RAB9AMAPK10MAOBMAOA | |
| SCHEMBL1666769 | 0.81 | MAOB (0.48) | NPC1RAB9AMAPK10MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |