Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665254 | 0.95 | SMO (0.57) | SMOMAPK10MAPK8KDRMAOB | |
| SCHEMBL1665395 | 0.91 | SMO (0.51) | SMOMEN1POLBKMT2AMAPK10 | |
| SCHEMBL1665083 | 0.90 | SMO (0.52) | SMOMEN1KMT2AMAPK10MAPK8 | |
| SCHEMBL1665085 | 0.85 | SMO (0.53) | SMOMEN1KMT2AMAPK10MAPK8 | |
| SCHEMBL1665396 | 0.85 | SMO (0.53) | SMOMEN1POLBKMT2AMAPK10 | |
| SCHEMBL1664622 | 0.84 | SMO (0.54) | SMOMAPK10MAPK8KDRMAOB | |
| SCHEMBL1664491 | 0.84 | NPC1 (0.58) | SMOMAPK10MAPK8MAOBNR3C1 | |
| SCHEMBL13836343 | 0.81 | MAOB (0.55) | MAPK10MAPK8KDRMAOBMAPK1 | |
| SCHEMBL1663552 | 0.81 | MEN1 (0.47) | SMOMEN1POLBKMT2AMAPK10 | |
| SCHEMBL27936989 | 0.81 | MAOB (0.50) | SMOMAPK10MAPK8KDRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |