Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25578541 | 0.89 | PPARG (0.45) | PPARGPPARACTSSCTSKTRPA1 | |
| SCHEMBL11915445 | 0.89 | PPARA (0.50) | PPARGPPARACTSSCTSKCTSL | |
| SCHEMBL11915449 | 0.89 | PPARA (0.50) | PPARGPPARACTSSCTSKCTSL | |
| SCHEMBL4074909 | 0.88 | CTSS (0.46) | KLK5PPARATACR1GSTP1GSTM2 | |
| SCHEMBL8232460 | 0.88 | KLK5 (0.45) | KLK5PPARGPPARATACR1GSTP1 | |
| SCHEMBL6560965 | 0.88 | CTSS (0.46) | KLK5PPARATACR1GSTP1GSTM2 | |
| SCHEMBL23963236 | 0.87 | PPARG (0.44) | KLK5PPARGPPARATACR1GSTP1 | |
| SCHEMBL20821189 | 0.87 | CTSS (0.47) | KLK5TACR1GSTP1GSTM2HDAC6 | |
| SCHEMBL18082636 | 0.87 | TRPA1 (0.52) | KLK5PPARGPPARATACR1GSTP1 | |
| SCHEMBL31751268 | 0.87 | TRPA1 (0.52) | KLK5PPARGPPARATACR1GSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015054658-A1 | MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE | SUTRO BIOPHARMA, INC. (US) | 2015-04-16 | — | — | WO | disclosed |