Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451929 | 0.83 | ALOX15 (0.45) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL6793608 | 0.79 | CA12 (0.56) | DHODHHTTALOX15MAPTALDH1A1 | |
| SCHEMBL6797385 | 0.79 | ROCK1 (0.60) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL21311026 | 0.79 | ROCK1 (0.48) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL27168484 | 0.79 | ALDH1A1 (0.47) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL30777212 | 0.79 | ALDH1A1 (0.47) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL30061686 | 0.79 | ALDH1A1 (0.47) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL6804452 | 0.78 | CA12 (0.48) | HTTALOX15MAPTALDH1A1KDM4E | |
| SCHEMBL31227531 | 0.78 | CA12 (0.45) | DHODHHTTALOX15MAPTALDH1A1 | |
| SCHEMBL11842891 | 0.77 | ALDH1A1 (0.49) | DHODHHTTMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |