Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.45 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | NEK2 | P51955 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | STK3 | Q13188 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16645938 | 0.89 | GRIN1 (0.55) | GRIN1GRIN2AGRIA2CD38P2RX7 | |
| SCHEMBL17958144 | 0.86 | GRIN1 (0.61) | GRIN1GRIN2AGRIA2P2RX7 | |
| SCHEMBL16645466 | 0.80 | GRIN1 (0.61) | GRIN1GRIN2AGRIA2CD38P2RX7 | |
| SCHEMBL17958237 | 0.78 | GRIN1 (0.73) | GRIN1GRIN2AGRIA2 | |
| SCHEMBL16645934 | 0.75 | GRIN1 (0.42) | GRIN1GRIN2AGRIA2CD38P2RX7 | |
| SCHEMBL16645507 | 0.73 | GRIN2A (0.53) | GRIN1GRIN2AGRIA2CD38LIMK1 | |
| SCHEMBL16645813 | 0.73 | GRIN1 (0.41) | GRIN1GRIN2AGRIA2CMA1 | |
| SCHEMBL16636460 | 0.73 | GRIN1 (0.77) | GRIN1GRIN2AGRIA2CD38 | |
| SCHEMBL16645506 | 0.72 | GRIN1 (0.70) | GRIN1GRIN2AGRIA2P2RX7 | |
| SCHEMBL16645746 | 0.72 | GRIN2A (0.51) | GRIN1GRIN2AGRIA2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052226-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |