Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16646169 | 0.89 | USP28 (0.49) | CYP2C9USP28 | |
| SCHEMBL12918707 | 0.89 | USP28 (0.49) | USP28 | |
| SCHEMBL1018441 | 0.88 | GAA (0.61) | CYP2C9GAA | |
| SCHEMBL12918705 | 0.88 | USP28 (0.48) | CYP2C9USP28 | |
| SCHEMBL16646161 | 0.88 | USP28 (0.48) | USP28 | |
| SCHEMBL16646061 | 0.88 | CYP2C9 (0.44) | CYP2C9USP28 | |
| SCHEMBL15425126 | 0.85 | USP28 (0.46) | USP28 | |
| SCHEMBL13628808 | 0.85 | USP28 (0.46) | CYP2C9USP28 | |
| SCHEMBL12918753 | 0.85 | USP28 (0.45) | CYP2C9USP28 | |
| SCHEMBL13628637 | 0.85 | TAS1R3 (0.48) | GAAUSP28 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152569-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2016-06-02 | — | — | US | disclosed |
| US-9321761-B2 | Pyridyl inhibitors of hedgehog signalling | CURIS, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20150105550-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | CURIS, INC. (US) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105550-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | XPO1 817/4885JUN 1106/4885NFKB1 1841/4885 |
| US-20160152569-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | XPO1 817/4885JUN 1106/4885NFKB1 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.