Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24404847 | 1.00 | NR1H2 (0.47) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL29017228 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL22078745 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL16633063 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL29239209 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL16633062 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL16633471 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL21193259 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL29017236 | 0.88 | NR1H2 (0.54) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 | |
| SCHEMBL22079700 | 0.87 | NR1H2 (0.46) | NR1H2SMN1; SMN2USP2RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105370-A1 | SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS | SSB, TLR7, TLR8 | NR1H2 333/4885SMN1; SMN2 4710/4885USP2 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.