Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 13/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664688 | 0.94 | HPGDS (0.51) | HPGDSMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1664890 | 0.89 | HPGDS (0.43) | HPGDSMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1664868 | 0.87 | HPGDS (0.57) | HPGDSALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL1663363 | 0.86 | HPGDS (0.56) | HPGDSALDH1A1PDE7AEGFR | |
| SCHEMBL1664362 | 0.86 | HPGDS (0.56) | HPGDSALDH1A1MAPTSMN1; SMN2PDE7A | |
| SCHEMBL1664943 | 0.86 | HPGDS (0.42) | HPGDSMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1664481 | 0.85 | SMN1; SMN2 (0.45) | HPGDSMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1664163 | 0.85 | SMN1; SMN2 (0.44) | HPGDSMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1666155 | 0.84 | HPGDS (0.56) | HPGDSPDE7AEGFR | |
| SCHEMBL1664557 | 0.84 | HPGDS (0.54) | HPGDSPDE7AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |