Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664702 | 0.90 | MEN1 (0.42) | HPGDSARNPC1RAB9A | |
| SCHEMBL8771316 | 0.86 | HPGDS (0.46) | HPGDSNPC1RAB9A | |
| SCHEMBL1666388 | 0.85 | HPGDS (0.46) | HPGDSJAK2JAK1JAK3TNIK | |
| SCHEMBL1666384 | 0.85 | HPGDS (0.48) | HPGDSJAK2JAK1JAK3TYK2 | |
| SCHEMBL1664979 | 0.81 | HPGDS (0.43) | HPGDSTNIKNPC1RAB9AMT-CO2 | |
| SCHEMBL1664928 | 0.80 | HPGDS (0.55) | HPGDSEGFRNPC1RAB9AMT-CO2 | |
| SCHEMBL1665814 | 0.79 | RAB9A (0.44) | HPGDSNPC1RAB9AGRM2MT-CO2 | |
| SCHEMBL1664977 | 0.79 | HPGDS (0.44) | HPGDSEGFRRAB9AGRM2MT-CO2 | |
| SCHEMBL1663366 | 0.77 | HPGDS (0.54) | HPGDSTNIKNPC1RAB9A | |
| SCHEMBL1667509 | 0.77 | HPGDS (0.54) | HPGDSTNIKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |