Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667400 | 0.97 | NPC1 (0.51) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1664865 | 0.97 | NPC1 (0.51) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1665855 | 0.90 | MAOA (0.53) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1664886 | 0.89 | MAOB (0.58) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1665857 | 0.89 | MAOA (0.52) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1664889 | 0.87 | MAOA (0.57) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1663845 | 0.85 | ESR1 (0.47) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL1663842 | 0.85 | MAOA (0.43) | NPC1RAB9AMAOAMAOBESR1 | |
| SCHEMBL6120725 | 0.84 | RAB9A (0.51) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL1664879 | 0.83 | NPC1 (0.41) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |