Cosyntropin

SCHEMBL16649201

CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C.[Zn+2]

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MC2R

The experimentally established mechanism targets of Cosyntropin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

	gene	UniProt	supporting neighbours	confidence
▸	C5AR1	P21730	2/20	0.74

▸	MC4R	P32245	3/20	0.71

▸	MC5R	P33032	2/20	0.71

▸	MC3R	P41968	2/20	0.71

▸	MC1R	Q01726	2/20	0.71

▸	GLP1R	P43220	4/20	0.64

▸	CTSL	P07711	3/20	0.63

▸	CTSS	P25774	3/20	0.63

▸	CTSK	P43235	3/20	0.63

▸	CTSH	P09668	1/20	0.63

▸	GCGR	P47871	3/20	0.62

▸	CXCR4	P61073	2/20	0.60

▸	KEAP1	Q14145	1/20	0.59

▸	PTH1R	Q03431	1/20	0.59

▸	IL23R	Q5VWK5	1/20	0.59

▸	NMBR	P28336	1/20	0.58

▸	GRPR	P30550	1/20	0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cosyntropin SCHEMBL720535	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL33366	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL27555834	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL29948667	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL522396	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL29383133	1.00	C5AR1 (0.74)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL25356191	0.99	C5AR1 (0.73)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL31252906	0.99	C5AR1 (0.73)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL16649167	0.99	C5AR1 (0.73)	C5AR1MC4RMC5RMC3RMC1R
Cosyntropin SCHEMBL563374	0.99	C5AR1 (0.73)	C5AR1MC4RMC5RMC3RMC1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20150110885-A1	PARENTERAL PHARMACEUTICAL COMPOSITION CONTAINING COSYNTROPIN	EMS S/A (BR)	2015-04-23	—	—	US	disclosed
EP-2862578-A1	Parenteral pharmaceutical composition containing cosyntropin	EMS S.A. (BR)	2015-04-22	—	—	EP	disclosed