Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cosyntropin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.74 |
| ▸ | MC4R | P32245 | 3/20 | 0.72 |
| ▸ | MC5R | P33032 | 2/20 | 0.72 |
| ▸ | MC3R | P41968 | 2/20 | 0.72 |
| ▸ | MC1R | Q01726 | 2/20 | 0.72 |
| ▸ | GLP1R | P43220 | 4/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSS | P25774 | 3/20 | 0.64 |
| ▸ | CTSK | P43235 | 3/20 | 0.64 |
| ▸ | CTSH | P09668 | 1/20 | 0.64 |
| ▸ | GCGR | P47871 | 3/20 | 0.63 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.59 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.59 |
| ▸ | NMBR | P28336 | 1/20 | 0.59 |
| ▸ | GRPR | P30550 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cosyntropin SCHEMBL720535 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL29948667 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL33366 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL29383133 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL522396 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL16649201 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL25356191 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL31252906 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL16649167 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL563374 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104244968-A | PH20 polypeptide variants, formulations, and uses thereof | HALOZYME INC | 2014-12-24 | — | — | CN | claimed |
| US-20250361240-A1 | PYRANOPYRIDINE COMPOUND, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | ZHEJIANG YANGLI PHARMACEUTICAL TECH CO LTD (CN) | 2025-11-27 | — | — | US | disclosed |
| EP-4650356-A1 | PYRANO-PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. (CN) | 2025-11-19 | — | — | EP | disclosed |
| CN-106536481-B | The composition of Parasiticidal comprising indole derivatives, its usage and purposes | 勃林格殷格翰动物保健美国公司 | 2019-11-22 | — | — | CN | disclosed |
| CN-105873925-B | Antiparasitic and insecticidal isoxazoline compounds | 勃林格殷格翰动物保健美国公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110177527-A | Device and method for adjusting insertion depth of needle for medicament delivery | 科尼尔赛德生物医学公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-110049757-A | Rapidly disintegrating pharmaceutical composition | 辉凌公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-108778330-A | With the method and apparatus of ophthalmic disorders after VEGF Trap and other biological products therapies | 科尼尔赛德生物医学公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-107835818-A | Anthelmintic depsipeptide compounds | 梅里亚股份有限公司 | 2018-03-23 | — | — | CN | disclosed |
| CN-104244968-B | PH20 polypeptide variants, formulation and its application | 哈洛齐梅公司 | 2017-07-25 | — | — | CN | disclosed |
| CN-105873925-A | Antiparasitic and insecticidal isoxazoline compounds | 梅里亚股份有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-104884049-A | Methods and devices for treating ocular diseases in human subjects | CLEARSIDE BIOMEDICAL INC | 2015-09-02 | — | — | CN | disclosed |
| CN-103159850-B | Preparation method of tetracosactide | SHENZHEN HYBIO PHARMACEUTICAL | 2015-04-22 | — | — | CN | disclosed |
| CN-104244968-A | PH20 polypeptide variants, formulations, and uses thereof | HALOZYME INC | 2014-12-24 | — | — | CN | disclosed |
| CN-102307993-B | Extended soluble ph20 polypeptides and uses thereof | HALOZYME INC | 2014-06-25 | — | — | CN | disclosed |
| CN-103205407-A | Extended soluble ph20 polypeptides and uses thereof | HALOZYME INC | 2013-07-17 | — | — | CN | disclosed |
| CN-103159850-A | Preparation method of tetracosactide | SHENZHEN HYBIO PHARMACEUTICAL | 2013-06-19 | — | — | CN | disclosed |
| CN-102492047-A | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine | FRESENIUS KABI DE GMBH | 2012-06-13 | — | — | CN | disclosed |
| CN-102307993-A | Extended soluble ph20 polypeptides and uses thereof | HALOZYME INC | 2012-01-04 | — | — | CN | disclosed |
| CN-1305490-A | Improved processing for preparing schift base adducts of amines with i(o)-hydroxy aldehydes and compositions of matter based thereon | PFIZER PROD INC (US) | 2001-07-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250361240-A1 | PYRANOPYRIDINE COMPOUND, PROCESS FOR PREPARING THE SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP11B1, CYP21A2, CYP11B2 | C5AR1 1514/4885MC4R 261/4885MC5R 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.