Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cosyntropin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.74 |
| ▸ | MC4R | P32245 | 3/20 | 0.72 |
| ▸ | MC5R | P33032 | 2/20 | 0.72 |
| ▸ | MC3R | P41968 | 2/20 | 0.72 |
| ▸ | MC1R | Q01726 | 2/20 | 0.72 |
| ▸ | GLP1R | P43220 | 4/20 | 0.64 |
| ▸ | CTSL | P07711 | 3/20 | 0.64 |
| ▸ | CTSS | P25774 | 3/20 | 0.64 |
| ▸ | CTSK | P43235 | 3/20 | 0.64 |
| ▸ | CTSH | P09668 | 1/20 | 0.64 |
| ▸ | GCGR | P47871 | 3/20 | 0.63 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.59 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.59 |
| ▸ | NMBR | P28336 | 1/20 | 0.59 |
| ▸ | GRPR | P30550 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cosyntropin SCHEMBL720535 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL29948667 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL27555834 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL29383133 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL522396 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL16649201 | 1.00 | C5AR1 (0.74) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL25356191 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL31252906 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL16649167 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R | |
| Cosyntropin SCHEMBL563374 | 0.99 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4562 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124148-A1 | POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY | BHAMIS RES LABORATORY PVT LTD (IN) | 2026-05-07 | — | — | US | claimed |
| EP-4728280-A1 | COMPOUNDS FOR DIAGNOSING AND TREATING EPILEPSY SYNDROMES, METHODS AND USES THEREOF | BIOSTRIKE UNIPESSOAL LDA (PT) | 2026-04-22 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260027062-A1 | IMPROVED ORAL PHARMACEUTICAL FORMULATIONS OF THERAPEUTIC PEPTIDES AND PROTEINS | CYPRUMED GMBH (AT) | 2026-01-29 | — | — | US | claimed |
| US-12533321-B2 | Polypeptide formulations for oral delivery | Bhami's Research Laboratory, Pvt. Ltd. (IN) | 2026-01-27 | — | — | US | claimed |
| EP-4601697-A2 | A FORMULATION FOR ORAL DELIVERY OF PEPTIDES AND BIOSIMILARS FOR SYSTEMIC ABSORPTION AND METHOD OF MANUFACTURING THE SAME | NBI Biosciences Pvt Ltd (IN) | 2025-08-20 | — | — | EP | claimed |
| EP-4601623-A1 | POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY | Bhami's Research Laboratory, Pvt. Ltd. (IN) | 2025-08-20 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-20250231192-A1 | DETECTION AND QUANTIFICATION OF ANTI-DRUG ANTIBODIES AND ANTI-SELF ANTIBODIES | PROMISE PROTEOMICS (FR) | 2025-07-17 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| WO-2001012155-A1 | COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS | LIPOCINE, INC. (US) | 2001-02-22 | — | — | WO | claimed |
| WO-2000013674-A1 | DOSAGE FORM COMPRISING THERAPEUTIC FORMULATION | ALZA CORPORATION (US) | 2000-03-16 | — | — | WO | claimed |
| US-5499979-A | Delivery system comprising kinetic forces | ALZA CORPORATION (US) | 1996-03-19 | — | — | US | claimed |
| EP-0491803-B1 | IMPLANTABLE DELIVERY DISPENSER | ALZA CORP (US) | 1994-07-20 | — | — | EP | claimed |
| EP-0491803-A1 | IMPLANTABLE DELIVERY DISPENSER. | ALZA CORP (US) | 1992-07-01 | — | — | EP | claimed |
| US-5112614-A | IMPLANTABLE DELIVERY DISPENSER | ALZA CORPORATION (US) | 1992-05-12 | — | — | US | claimed |
| US-5023088-A | Drug delivery dispenser | ALZA CORPORATION (US) | 1991-06-11 | — | — | US | claimed |
| WO-1991004016-A1 | IMPLANTABLE DELIVERY DISPENSER | ALZA CORPORATION (US) | 1991-04-04 | — | — | WO | claimed |
| US-4957494-A | Multi-layer delivery system | ALZA CORPORATION (US) | 1990-09-18 | — | — | US | claimed |
| US-4127537-A | ANALGESIC | VETERANS ADMINISTRATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY | 1978-11-28 | — | — | US | claimed |