Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | KDM1A | O60341 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055279 | 0.85 | HTR2C (0.56) | HTR2CMAOBKDM1A | |
| SCHEMBL12813766 | 0.79 | KDM1A (0.63) | HTR2CMAOBKDM1AKCNH2CYP3A4 | |
| SCHEMBL12813765 | 0.79 | KDM1A (0.63) | HTR2CMAOBKDM1AKCNH2CYP3A4 | |
| SCHEMBL28537486 | 0.79 | HTR2C (0.47) | HTR2CMAOBKDM1AKCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL15091771 | 0.77 | HTR2C (0.62) | HTR2CMAOBKDM1AKCNH2CYP2C19 | |
| Hydrochloric Acid SCHEMBL15091773 | 0.77 | HTR2C (0.62) | HTR2CMAOBKDM1AKCNH2CYP2C19 | |
| SCHEMBL3346427 | 0.76 | KCNH2 (0.57) | HTR2CKCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16649818 | 0.76 | KDM1A (0.69) | KDM1AKCNH2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL15729989 | 0.76 | SLC6A3 (0.44) | HTR2CMAOBKDM1A | |
| SCHEMBL14813595 | 0.76 | HTR2C (0.43) | HTR2CMAOBKDM1AKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |