Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | MPL | P40238 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649567 | 1.00 | IDO1 (0.47) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL4234796 | 0.82 | IDO1 (0.51) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL21132890 | 0.82 | IDO1 (0.47) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL29656429 | 0.82 | IDO1 (0.51) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL29845425 | 0.82 | IDO1 (0.51) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL25019477 | 0.82 | IDO1 (0.47) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL14120782 | 0.82 | IDO1 (0.51) | IDO1TDO2P2RX7CCR1PDE2A | |
| SCHEMBL4550765 | 0.82 | IDO1 (0.51) | IDO1TDO2P2RX7CCR1PDE2A | |
| Hydrochloric Acid SCHEMBL25358651 | 0.81 | IDO1 (0.54) | IDO1TDO2P2RX7CCR1PDE2A | |
| Hydrochloric Acid SCHEMBL2716131 | 0.81 | IDO1 (0.54) | IDO1TDO2P2RX7CCR1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133187-B2 | Serine/threonine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-15 | — | — | US | claimed |
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |