Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14846893 | 1.00 | ADRB2 (0.41) | ADRB2LMNATP53HTTAPLNR | |
| SCHEMBL11087333 | 0.79 | APLNR (0.34) | APLNRCYP1A2 | |
| SCHEMBL13943922 | 0.77 | APLNR (0.54) | APLNR | |
| SCHEMBL14677407 | 0.77 | APLNR (0.54) | APLNR | |
| SCHEMBL22481548 | 0.77 | APLNR (0.33) | APLNR | |
| SCHEMBL23230046 | 0.75 | CHRNA7 (0.33) | ADRB2APLNR | |
| SCHEMBL219272 | 0.75 | APLNR (0.33) | APLNR | |
| SCHEMBL12067749 | 0.75 | APLNR (0.33) | APLNR | |
| SCHEMBL219540 | 0.75 | APLNR (0.33) | APLNR | |
| SCHEMBL20322898 | 0.75 | KDM4E (0.35) | HTTAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |