Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.30 |
| ▸ | ERBB2 known ✓ | P04626 | 1/20 | 0.30 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649909 | 0.92 | PARK7 (0.42) | PARK7KDM4EGAAALDH1A1 | |
| SCHEMBL16649950 | 0.89 | PARK7 (0.46) | PARK7KDM4EGAAALDH1A1 | |
| SCHEMBL16649823 | 0.77 | PARK7 (0.48) | PARK7KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL351947 | 0.76 | PARK7 (0.46) | PARK7KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL16650125 | 0.74 | PARK7 (0.32) | PARK7 | |
| SCHEMBL354623 | 0.73 | KDM4E (0.39) | PARK7KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL351919 | 0.72 | PARK7 (0.50) | PARK7KDM4EGAAMAPTALDH1A1 | |
| SCHEMBL352431 | 0.71 | PARK7 (0.56) | PARK7MAPTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL353999 | 0.68 | PARK7 (0.46) | PARK7KDM4EALDH1A1 | |
| SCHEMBL350823 | 0.68 | PARK7 (0.54) | PARK7KDM4EMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411376-B1 | INHIBITORS OF NF-KB | PROFECTUS BIOSCIENCES INC (US) | 2015-04-22 | — | — | EP | claimed |