Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15157445 | 0.81 | KIF11 (0.50) | KIF11APPKDM1A | |
| SCHEMBL16649936 | 0.80 | KIF11 (0.47) | KIF11APPNR3C2P2RX7KDM1A | |
| SCHEMBL16649910 | 0.77 | KIF11 (0.47) | KIF11APPKDM1A | |
| SCHEMBL3182714 | 0.77 | KIF11 (0.51) | KIF11KDRKDM1AKCNQ3KCNQ2 | |
| SCHEMBL12498442 | 0.77 | IDO1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL27642819 | 0.73 | KIF11 (0.54) | KIF11KDM1A | |
| SCHEMBL9903507 | 0.73 | MAOB (0.45) | KDM4E | |
| SCHEMBL48409 | 0.72 | KIF11 (0.73) | KIF11KDM1AKDM4EALDH1A1 | |
| SCHEMBL29438427 | 0.72 | KIF11 (0.73) | KIF11KDM1AKDM4EALDH1A1 | |
| SCHEMBL13358948 | 0.72 | NR3C2 (0.40) | KIF11APPNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |