Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406998 | 0.82 | PBRM1 (0.34) | — | |
| SCHEMBL16649861 | 0.74 | PBRM1 (0.32) | KDM4E | |
| SCHEMBL5800279 | 0.69 | CES2 (0.39) | — | |
| SCHEMBL16649255 | 0.67 | CDC7 (0.34) | — | |
| SCHEMBL16649739 | 0.67 | CES2 (0.32) | — | |
| SCHEMBL12497720 | 0.66 | CDC7 (0.35) | — | |
| SCHEMBL8676513 | 0.66 | PBRM1 (0.43) | ALDH1A1GAA | |
| SCHEMBL15512168 | 0.66 | PBRM1 (0.33) | — | |
| SCHEMBL12497243 | 0.65 | PBRM1 (0.35) | CD38 | |
| SCHEMBL12497303 | 0.64 | CDC7 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |