Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649255 | 0.82 | CDC7 (0.34) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL12497303 | 0.82 | CDC7 (0.34) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL9902431 | 0.79 | CDC7 (0.35) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL12497720 | 0.79 | CDC7 (0.35) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL16649116 | 0.74 | CDC7 (0.33) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL16649861 | 0.71 | PBRM1 (0.32) | — | |
| SCHEMBL15511847 | 0.70 | CASP1 (0.33) | — | |
| SCHEMBL15512168 | 0.69 | PBRM1 (0.33) | — | |
| SCHEMBL16649590 | 0.68 | NOTUM (0.33) | CDC7PLK4DYRK3JAK2ROCK2 | |
| SCHEMBL6802928 | 0.68 | DYRK1A (0.33) | CDC7PLK4DYRK3JAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |