Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 9/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16649916 | 0.80 | PARK7 (0.58) | IRAK4IRAK1NPC1RAB9APDGFRB | |
| SCHEMBL354123 | 0.80 | BRD4 (0.44) | NPC1RAB9AMAPTTSHRSMN1; SMN2 | |
| SCHEMBL352796 | 0.79 | EGLN1 (0.47) | NPC1RAB9AMAPTPOLBCASP3 | |
| SCHEMBL353219 | 0.75 | PRKCI (0.35) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL352275 | 0.73 | SMN1; SMN2 (0.37) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL30616306 | 0.73 | PDGFRB (0.64) | IRAK4IRAK1NPC1RAB9APDGFRB | |
| SCHEMBL30616268 | 0.71 | PDGFRB (0.66) | IRAK4IRAK1NPC1RAB9APDGFRB | |
| SCHEMBL29812587 | 0.71 | PDGFRB (0.60) | IRAK4IRAK1NPC1RAB9APDGFRB | |
| SCHEMBL28839474 | 0.70 | PDGFRB (0.64) | IRAK4IRAK1NPC1RAB9APDGFRB | |
| SCHEMBL30229311 | 0.70 | PDGFRB (0.64) | IRAK4IRAK1NPC1RAB9APDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411376-B1 | INHIBITORS OF NF-KB | PROFECTUS BIOSCIENCES INC (US) | 2015-04-22 | — | — | EP | claimed |