SCHEMBL16650601

SCHEMBL16650601

Cc1c(Br)cn(C)c(=O)c1C

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 9/20 0.34
BRD9 Q9H8M2 3/20 0.34
BRD7 Q9NPI1 3/20 0.34
BRD2 P25440 2/20 0.34
MAP2K1 Q02750 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15068063 0.80 AURKA (0.33) BRD4BRD9
SCHEMBL22990247 0.80 MAP2K1 (0.35) BRD4MAP2K1
SCHEMBL20704658 0.80 BRD4 (0.33) BRD4
SCHEMBL31180641 0.80 MAP2K1 (0.33) BRD4MAP2K1
SCHEMBL20704443 0.77 BRD4 (0.33) BRD4BRD9BRD7BRD2
SCHEMBL3450311 0.77 GPR35 (0.37) BRD4BRD9MAP2K1
SCHEMBL20709909 0.76 MAPT (0.41)
SCHEMBL23201571 0.75 BRD4 (0.41) BRD4BRD9BRD7BRD2
SCHEMBL9279323 0.74 BRD4 (0.37) BRD4BRD9BRD7BRD2
SCHEMBL15067937 0.74 GRIN2D (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117229202-B Preparation method of intermediate of BRD9 targeted degradation compound 苏州美诺医药科技有限公司 2024-01-26 CN claimed
CN-117229202-A Preparation method of intermediate of BRD9 targeted degradation compound 苏州美诺医药科技有限公司 2023-12-15 CN claimed
US-12624035-B2 Compounds for targeted protein degradation AMPHISTA THERAPEUTICS LIMITED (GB) 2026-05-12 US disclosed
EP-4720040-A1 SULFONAMIDE COMPOUNDS BENEFICIAL IN NEUROPROTECTIVE TREATMENT Lario Therapeutics Limited (GB) 2026-04-08 EP disclosed
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LTD (GB) 2026-04-02 US disclosed
US-20260070904-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION AMPHISTA THERAPEUTICS LIMITED (GB) 2026-03-12 US disclosed
US-12384760-B2 Substituted carbazole compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-12 US disclosed
EP-4134364-B1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RES INC (US) 2025-07-30 EP disclosed
US-20250195484-A1 CEREBLON LIGANDS AND USES THEREOF UNIV MICHIGAN (US) 2025-06-19 US disclosed
CN-119823124-A Compounds for targeted degradation of BRD9 C4医药公司 2025-04-15 CN disclosed
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 C4 THERAPEUTICS, INC. (US) 2025-03-13 US disclosed
US-20150183784-A1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-07-02 US disclosed
US-9034900-B2 Bromodomain inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-05-19 US disclosed
US-9034900-B2 Bromodomain inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-05-19 US disclosed
US-9034900-B2 Bromodomain inhibitors Quanticel Pharmaceuticals, Inc. (US) 2015-05-19 US disclosed
WO-2015058160-A1 BROMODOMAIN INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2015-04-23 WO disclosed
WO-2015058160-A1 BROMODOMAIN INHIBITORS Quanticel Pharmaceuticals, Inc. (US) 2015-04-23 WO disclosed
US-20150111885-A1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-04-23 US disclosed
US-20150111885-A1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-04-23 US disclosed
US-20150111885-A1 BROMODOMAIN INHIBITORS CELGENE QUANTICEL RESEARCH, INC. 2015-04-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250195484-A1 CEREBLON LIGANDS AND USES THEREOF CRBN, CDR2, CHLSN BRD4 1042/4885BRD9 820/4885BRD7 370/4885
US-20260070904-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BRD9, BRWD1, BRD1 BRD4 14/4885BRD9 1/4885BRD7 9/4885
US-20150111885-A1 BROMODOMAIN INHIBITORS BRD3, EP300, BRPF3 BRD4 5/4885BRD9 19/4885BRD7 14/4885
US-12624035-B2 Compounds for targeted protein degradation BRD9, BRD1, BRD3 BRD4 9/4885BRD9 1/4885BRD7 7/4885
US-20260092061-A1 COMPOUNDS FOR TARGETED PROTEIN DEGRADATION BCL9L, RBBP9, BRD9 BRD4 161/4885BRD9 3/4885BRD7 18/4885
US-20150183784-A1 BROMODOMAIN INHIBITORS BRD3, EP300, BRPF3 BRD4 5/4885BRD9 19/4885BRD7 14/4885
US-20250084081-A1 COMPOUNDS FOR TARGETED DEGRADATION OF BRD9 BRD9, BRD1, BRWD1 BRD4 30/4885BRD9 1/4885BRD7 8/4885
US-12384760-B2 Substituted carbazole compounds TLR7, TLR3, TLR1 BRD4 169/4885BRD9 456/4885BRD7 98/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.