Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665077 | 0.92 | MAOB (0.43) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL1666461 | 0.89 | MAPT (0.50) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL6126509 | 0.87 | SMN1; SMN2 (0.45) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL1666888 | 0.86 | IRAK4 (0.42) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL13964705 | 0.85 | MAPT (0.52) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL1664777 | 0.84 | MAPK10 (0.41) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL6126290 | 0.84 | CHRNA7 (0.51) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL1664957 | 0.84 | MGLL (0.43) | MAPK10MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6126314 | 0.84 | RAB9A (0.56) | NPC1RAB9AMAPK10MAPK13MAPK12 | |
| SCHEMBL1665369 | 0.83 | MAPT (0.43) | NPC1RAB9AMAPK10MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |