Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2780637 | 0.77 | CYP2C19 (0.36) | CYP2C19KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL2780642 | 0.77 | CYP2C19 (0.36) | CYP2C19KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL31510224 | 0.76 | APP (0.52) | CYP2C19KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL31510225 | 0.76 | APP (0.52) | CYP2C19KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL854913 | 0.76 | APP (0.33) | — | |
| SCHEMBL9227835 | 0.76 | AHR (0.48) | KDM4EALDH1A1CYP2A6MAPTNFE2L2 | |
| SCHEMBL9227488 | 0.76 | NFE2L2 (0.60) | CYP2C19RAB9ACYP2A6MAPTCYP3A4 | |
| SCHEMBL9227484 | 0.76 | NFE2L2 (0.60) | CYP2C19RAB9ACYP2A6MAPTCYP3A4 | |
| SCHEMBL9679616 | 0.76 | ALDH1A1 (0.61) | CYP2C19KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL9679607 | 0.76 | ALDH1A1 (0.61) | CYP2C19KDM4EALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369023-B | Synthesis method and application of 2-aryl acrylate | 华南理工大学 | 2023-01-06 | — | — | CN | disclosed |
| CN-114369023-A | Synthesis method and application of 2-aryl acrylate | 华南理工大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-108658716-B | Method for synthesizing olefin compound by photoinduction one-pot method | 清华大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-109651191-A | A kind of difluoromethyl oxime ether derivatives and its synthetic method | 华南理工大学 | 2019-04-19 | — | — | CN | disclosed |
| WO-2014035872-A1 | TRICYCLIC ALKYNES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN | AMGEN INC. (US) | 2014-03-06 | — | — | WO | disclosed |
| WO-2013123444-A1 | SULFONYL COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN | AMGEN INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |