SCHEMBL1665260

SCHEMBL1665260

CCOC(=O)C1=C(C)NC(c2ccccc2)=C(C(=O)OCC)C1c1cccnc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.68
MAPK1 P28482 1/20 0.68
ALDH1A1 P00352 2/20 0.67
GAA P10253 3/20 0.66
NPSR1 Q6W5P4 3/20 0.64
CYP3A4 P08684 2/20 0.64
CYP2C9 P11712 2/20 0.64
CYP2C19 P33261 2/20 0.64
CYP2D6 P10635 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.62
TSHR P16473 3/20 0.60
CACNA1B Q00975 1/20 0.59
ADORA3 P0DMS8 4/20 0.59
KDM4E B2RXH2 1/20 0.58
HPGD P15428 1/20 0.58
CASP1 P29466 1/20 0.58
CASP7 P55210 1/20 0.58
HSD17B10 Q99714 1/20 0.58
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7159081 0.88 TSHR (0.70) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL1664685 0.88 ADORA3 (0.71) MAPTALDH1A1GAASMN1; SMN2TSHR
SCHEMBL9765796 0.86 CACNA1B (0.73) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL11868720 0.84 TSHR (0.65) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL11877364 0.84 TSHR (0.65) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL7161996 0.84 ADORA3 (0.73) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL11521974 0.82 TSHR (0.62) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL7267796 0.81 CACNA1F (0.57) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL11524058 0.80 ADORA3 (0.63) MAPTMAPK1ALDH1A1GAANPSR1
SCHEMBL1664958 0.80 KDM4E (0.80) ALDH1A1GAACYP2C9CYP2C19ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885192-B8 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) 2012-05-16 EP disclosed
EP-2311806-A2 Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists The United States of America, Represented by the Secretary, Department of Health and Human Services (US) 2011-04-20 EP disclosed
US-6066642-A FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-05-23 US disclosed
EP-0885192-A1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1998-12-23 EP disclosed
WO-1997027177-A2 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-07-31 WO disclosed