Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.71 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.60 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.55 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027412 | 0.89 | ADORA3 (0.89) | ADORA3KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1665260 | 0.88 | MAPT (0.68) | ADORA3TMIGD3KDM4EALDH1A1TSHR | |
| SCHEMBL11691626 | 0.86 | ADORA3 (0.56) | ADORA3TMIGD3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7687629 | 0.85 | ADORA3 (0.75) | ADORA3TMIGD3KDM4EALDH1A1TRPV1 | |
| SCHEMBL29173863 | 0.85 | ADORA3 (0.82) | ADORA3KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10684386 | 0.83 | ADORA3 (0.75) | ADORA3KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL20610477 | 0.83 | ADORA3 (1.00) | ADORA3KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11860075 | 0.83 | ADORA3 (0.80) | ADORA3KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11691621 | 0.83 | ADORA3 (0.56) | ADORA3TMIGD3KDM4EALDH1A1TSHR | |
| SCHEMBL1664958 | 0.83 | KDM4E (0.80) | ADORA3TMIGD3KDM4EALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311806-A2 | Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists | The United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2011-04-20 | — | — | EP | disclosed |
| US-6066642-A | FOR SELECTIVELY BLOCKING THE A3 ADENOSINE RECEPTOR OF A MAMMAL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-05-23 | — | — | US | disclosed |