Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907563 | 0.92 | LMNA (0.59) | MAPTNPC1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL16182652 | 0.90 | MAPT (0.53) | MAPTNPC1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL28487045 | 0.85 | ALDH1A1 (0.60) | MAPTNPC1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL27816716 | 0.83 | TSHR (0.62) | MAPTNPC1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL28487967 | 0.83 | TSHR (0.62) | MAPTNPC1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL1665977 | 0.83 | MAPT (0.70) | MAPTNPC1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL8189712 | 0.81 | TSHR (0.56) | MAPTTSHRKMT2ACYP1A2CYP2C9 | |
| SCHEMBL10911733 | 0.80 | TSHR (0.54) | NPC1SMN1; SMN2RAB9ATSHRKMT2A | |
| SCHEMBL16182654 | 0.80 | ALDH1A1 (0.55) | MAPTNPC1SMN1; SMN2RAB9ATSHR | |
| SCHEMBL28490591 | 0.79 | MAPT (0.65) | MAPTNPC1SMN1; SMN2RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2314581-B1 | A process for preparing benzo[b]thiophene derivatives | HEXAL AG (DE) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011047877-A1 | A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES | HEXAL AKTIENGESELLSCHAFT (DE) | 2011-04-28 | — | — | WO | disclosed |
| EP-2314581-A1 | A process for preparing benzo[b]thiophene derivatives | Hexal AG (DE) | 2011-04-27 | — | — | EP | disclosed |