Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1665398 | 0.97 | EGFR (0.44) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1665404 | 0.97 | EGFR (0.44) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1667332 | 0.89 | MAPT (0.48) | RAB9ANPC1USP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1666904 | 0.89 | NPC1 (0.47) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1664879 | 0.89 | NPC1 (0.41) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1666906 | 0.87 | RAB9A (0.50) | RAB9ANPC1USP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1664139 | 0.86 | ALDH1A1 (0.44) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1664881 | 0.86 | NPC1 (0.45) | EGFRRAB9ANPC1USP2SMN1; SMN2 | |
| SCHEMBL1664099 | 0.86 | NPC1 (0.41) | EGFRRAB9ANPC1USP2ALDH1A1 | |
| SCHEMBL1663777 | 0.86 | NPC1 (0.45) | EGFRRAB9ANPC1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |