SCHEMBL1665408

SCHEMBL1665408

O=C(O)CNc1ccc(-n2ncc3cc(Nc4ccc(N5CCOCC5)cc4)ccc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 11/20 0.49
MAPK8 P45983 8/20 0.49
MAPK13 O15264 4/20 0.49
MAPK12 P53778 4/20 0.49
MAPK11 Q15759 4/20 0.49
MAPK14 Q16539 4/20 0.49
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.43
STAT6 P42226 2/20 0.42
PIN1 Q13526 1/20 0.42
TP53 P04637 1/20 0.41
MAPK1 P28482 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
RAC1 P63000 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1665410 0.88 MAPT (0.52) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL1666104 0.80 MAPT (0.46) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL1664258 0.80 JAK2 (0.48) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL6625019 0.80 L3MBTL1 (0.58) MAPTALDH1A1L3MBTL1SMN1; SMN2KDM4E
SCHEMBL1664056 0.80 GSK3B (0.44) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL1664913 0.79 MAPT (0.59) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL8769687 0.79 MAPT (0.54) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL1664618 0.78 MAPT (0.46) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL1664701 0.78 MAPT (0.46) MAPK10MAPK8MAPK13MAPK12MAPK11
SCHEMBL13974299 0.76 MAPT (0.49) MAPK10MAPK8MAPK13MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2642994-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS Ligand Pharmaceuticals Incorporated (US) 2013-10-02 EP disclosed
EP-2488486-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES Ligand Pharmaceuticals Inc. (US) 2012-08-22 EP disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 WO disclosed