Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28891048 | 0.81 | CHRNA7 (0.45) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL5544683 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL374222 | 0.78 | SIRT6 (0.68) | MAPTSMN1; SMN2ALDH1A1LMNASIRT6 | |
| SCHEMBL3282015 | 0.77 | POLB (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL591314 | 0.77 | MAPT (0.45) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL21596383 | 0.75 | GAA (0.62) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL7589840 | 0.75 | GAA (0.53) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL2927491 | 0.72 | GAA (0.55) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL29608091 | 0.72 | MAPT (0.67) | MAPTSMN1; SMN2GAARAD52KDM4E | |
| SCHEMBL611726 | 0.72 | MAPT (0.67) | MAPTSMN1; SMN2GAARAD52KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |