Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | RAD52 | P43351 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | GFER | P55789 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574835 | 0.81 | MAPT (0.58) | GAAMAPTGFERKDM4ESMN1; SMN2 | |
| SCHEMBL7589840 | 0.80 | GAA (0.53) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL9213288 | 0.78 | ALDH1A1 (0.50) | GAAMAPTKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL158007 | 0.77 | MAPT (1.00) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL6152136 | 0.77 | MAPT (1.00) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL17728862 | 0.75 | GAA (0.56) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL16654093 | 0.75 | MAPT (0.47) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL574469 | 0.74 | LGMN (0.50) | GAAMAPTKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL3847676 | 0.72 | GAA (0.76) | GAARAD52MAPTGFERKDM4E | |
| SCHEMBL30724194 | 0.72 | GAA (0.76) | GAARAD52MAPTGFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |