Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581725 | 0.91 | SMN1; SMN2 (0.47) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL14167702 | 0.89 | ALDH1A1 (0.40) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL14638247 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL21811379 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL1441341 | 0.83 | SMN1; SMN2 (0.36) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL2484547 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBTP53ALDH1A1GAA | |
| SCHEMBL1710473 | 0.78 | BTK (0.49) | POLB | |
| SCHEMBL14167555 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL18132141 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBTP53ALDH1A1 | |
| SCHEMBL1297555 | 0.77 | CHRNB2 (0.62) | SMN1; SMN2BRD4CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057954-A2 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Syros Pharmaceuticals, Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |