Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30344322 | 0.84 | CHRNB2 (0.59) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL311014 | 0.84 | CHRNB2 (0.59) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL213189 | 0.83 | CHRNB2 (0.62) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL30578533 | 0.81 | MAPT (0.61) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL8915357 | 0.81 | MAPT (0.61) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL10137307 | 0.80 | CHRNB2 (0.58) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL30380932 | 0.80 | CHRNB2 (0.58) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL1962346 | 0.80 | CHRNB2 (0.58) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL109773 | 0.80 | MAPT (0.72) | CHRNB2CHRNA4KDM4EGAAMAPT | |
| SCHEMBL28044446 | 0.80 | CHRNB2 (0.54) | CHRNB2CHRNA4KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |