Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665206 | 0.85 | KDR (0.44) | KDRFGFR1EPHB4AURKA | |
| SCHEMBL16665205 | 0.83 | L3MBTL1 (0.51) | KDRFGFR1EPHB4 | |
| SCHEMBL16665212 | 0.77 | KDR (0.50) | KDRFGFR1EPHB4AURKA | |
| SCHEMBL18793023 | 0.75 | KDR (0.51) | KDRFGFR1EPHB4AURKA | |
| SCHEMBL16655795 | 0.75 | L3MBTL1 (0.44) | KDRFGFR1EPHB4AURKA | |
| SCHEMBL16665207 | 0.74 | KDR (0.46) | KDRFGFR1EPHB4AURKA | |
| SCHEMBL13980512 | 0.73 | KDR (0.52) | KDRFGFR1EPHB4 | |
| SCHEMBL18793161 | 0.73 | KDR (0.74) | KDRAURKA | |
| SCHEMBL16665217 | 0.72 | MAPK3 (0.48) | FGFR1 | |
| SCHEMBL18793228 | 0.71 | KDR (0.72) | KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |