Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665217 | 0.89 | MAPK3 (0.48) | L3MBTL1EGFRMAPK3MAPK1MAP2K1 | |
| SCHEMBL16665245 | 0.84 | FGFR4 (0.50) | EGFRMAPK3FGFR1FGFR4 | |
| SCHEMBL16655795 | 0.84 | L3MBTL1 (0.44) | L3MBTL1EGFRKDRJAK3BTK | |
| SCHEMBL16655392 | 0.83 | KDR (0.48) | KDRFGFR1EPHB4 | |
| SCHEMBL16665222 | 0.82 | L3MBTL1 (0.45) | L3MBTL1EGFRMAPK3KDRMAPK1 | |
| SCHEMBL13169364 | 0.77 | MAPK3 (0.50) | EGFRMAPK3MAPK1MAP2K1FGFR4 | |
| SCHEMBL16665212 | 0.76 | KDR (0.50) | KDRJAK3FGFR1EPHB4 | |
| SCHEMBL18793023 | 0.74 | KDR (0.51) | KDRJAK3FGFR1EPHB4 | |
| SCHEMBL16665207 | 0.74 | KDR (0.46) | L3MBTL1EGFRKDRMAPK1FGFR1 | |
| SCHEMBL16665206 | 0.73 | KDR (0.44) | KDRFGFR1EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |