Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589356 | 0.77 | SIRT6 (0.55) | MAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL28989562 | 0.75 | MAPT (0.51) | KMT2AMAPTSMN1; SMN2NPSR1L3MBTL1 | |
| SCHEMBL589217 | 0.74 | MAPT (0.38) | KMT2AMAPTALDH1A1SIGMAR1 | |
| SCHEMBL28891048 | 0.73 | CHRNA7 (0.45) | KMT2AMAPTSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL1044823 | 0.73 | HTT (0.61) | HTTKMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1044822 | 0.73 | HTT (0.61) | HTTKMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1399606 | 0.73 | HTT (0.61) | HTTKMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL6189229 | 0.72 | MAPT (0.54) | KMT2AMAPTSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL23122152 | 0.72 | SIRT6 (0.60) | HTTKMT2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL16654439 | 0.72 | KMT2A (0.50) | HTTKMT2AMAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |