Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | IDE | P14735 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28989562 | 0.84 | MAPT (0.51) | MAPTALDH1A1SMN1; SMN2NPSR1POLB | |
| SCHEMBL589356 | 0.83 | SIRT6 (0.55) | MAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL28891048 | 0.79 | CHRNA7 (0.45) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL589160 | 0.78 | LMNA (0.59) | MAPTALDH1A1SMN1; SMN2CYP2C9HPGD | |
| SCHEMBL3282015 | 0.78 | POLB (0.54) | MAPTPKMALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL589217 | 0.77 | MAPT (0.38) | MAPTALDH1A1POLBHPGDMAPK1 | |
| SCHEMBL591314 | 0.75 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2HPGDLMNA | |
| SCHEMBL541488 | 0.74 | LMNA (0.47) | MAPTALDH1A1SMN1; SMN2LMNAAKR1C3 | |
| SCHEMBL18036523 | 0.73 | MAPT (0.75) | MAPTPKMALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL16655434 | 0.72 | HTT (0.47) | MAPTALDH1A1SMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585727-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | Akzo Nobel N.V. (NL) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004041782-A1 | INDOLES USEFUL IN THE TREATMENT OF ANDROGEN-RECEPTOR RELATED DISEASES | AKZO NOBEL N.V. (NL) | 2004-05-21 | — | — | WO | disclosed |