Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554748 | 0.86 | MAP4K4 (0.54) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8241275 | 0.85 | KDM4E (0.58) | CLK4POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1666752 | 0.81 | CYP1A2 (0.64) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28531568 | 0.80 | CLK4 (0.58) | CLK4POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4648432 | 0.79 | ALDH1A1 (0.54) | CLK4POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13504222 | 0.75 | CLK4 (0.68) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4644302 | 0.75 | RAB9A (0.58) | CLK4POLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15534955 | 0.75 | CYP1A2 (0.49) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14554854 | 0.74 | MEN1 (0.48) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL14486807 | 0.74 | SLC2A1 (0.46) | CLK4POLBDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |