Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.53 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16651686 | 0.85 | ALDH1A1 (0.54) | KDM4ETDP1POLBMAPK1MEN1 | |
| SCHEMBL29293873 | 0.83 | KDM4E (0.57) | KDM4ETDP1POLBKCNK2KCNK10 | |
| SCHEMBL140563 | 0.80 | TDP1 (0.73) | KDM4ETDP1POLBAPEX1MAPK1 | |
| SCHEMBL29440123 | 0.80 | TDP1 (0.73) | KDM4ETDP1POLBAPEX1MAPK1 | |
| SCHEMBL8689243 | 0.80 | TDP1 (0.68) | KDM4ETDP1POLBAPEX1MAPK1 | |
| SCHEMBL582448 | 0.79 | KDM4E (0.67) | KDM4ETDP1POLBMAPK1MEN1 | |
| SCHEMBL7532175 | 0.78 | POLB (0.68) | KDM4ETDP1POLBAPEX1MAPK1 | |
| SCHEMBL15647380 | 0.75 | KMT2A (0.67) | KDM4ETDP1POLBMAPK1MEN1 | |
| SCHEMBL111313 | 0.73 | ALDH1A1 (0.76) | KDM4ETDP1POLBAPEX1KCNK2 | |
| SCHEMBL11712354 | 0.73 | KMT2A (0.63) | POLBMEN1KMT2ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057422-A1 | QUINOLINYL MODULATORS OF ROR(GAMMA)T | Janssen Pharmaceutica NV (BE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057626-A1 | QUINOLINYL MODULATORS OF RORyT | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-23 | — | — | WO | disclosed |