Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.55 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.49 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29440123 | 0.87 | TDP1 (0.73) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL140563 | 0.87 | TDP1 (0.73) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL8688878 | 0.85 | KMT2A (0.55) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL7532175 | 0.84 | POLB (0.68) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL16650906 | 0.83 | ALDH1A1 (0.60) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL8484239 | 0.82 | KCNK2 (0.49) | TDP1KDM4EPOLBALDH1A1MAPT | |
| SCHEMBL8482804 | 0.82 | KDM4E (0.64) | KDM4EPOLBMEN1KMT2AAKR1C2 | |
| SCHEMBL15647380 | 0.81 | KMT2A (0.67) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6354673 | 0.81 | NPC1 (0.59) | TDP1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL16655841 | 0.80 | KDM4E (0.68) | TDP1KDM4EPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741926-A | ANTIDIABETIC AGENT | SHAMAN PHARMACEUTICALS, INC. (US) | 1998-04-21 | — | — | US | disclosed |
| WO-1997030019-A1 | ANILINE DERIVATIVES HAVING ANTIHYPERGLYCEMIC ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-08-21 | — | — | WO | disclosed |