Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 11/20 | 0.43 |
| ▸ | CA1 | P00915 | 9/20 | 0.43 |
| ▸ | CA9 | Q16790 | 9/20 | 0.43 |
| ▸ | CA12 | O43570 | 9/20 | 0.43 |
| ▸ | CA7 | P43166 | 5/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.43 |
| ▸ | CA4 | P22748 | 4/20 | 0.43 |
| ▸ | CA6 | P23280 | 4/20 | 0.43 |
| ▸ | CA5A | P35218 | 4/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013203 | 0.81 | KIF11 (0.53) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL3534174 | 0.81 | KIF11 (0.45) | KIF11CTNNB1WNT3ARAB9ANOTUM | |
| SCHEMBL4558462 | 0.76 | CNR1 (0.60) | CA2CA1CA9CA12CA7 | |
| SCHEMBL13194642 | 0.74 | CA2 (0.51) | CA2CA1CA9CA12CA7 | |
| SCHEMBL16135859 | 0.72 | SMYD3 (0.51) | LMNARAB9AMAPTPKMNPC1 | |
| SCHEMBL3633865 | 0.71 | CA2 (0.46) | CA2CA1CA9CA12CA7 | |
| SCHEMBL21807839 | 0.70 | KIF11 (0.45) | KIF11CTNNB1WNT3ARAB9APKM | |
| SCHEMBL167634 | 0.70 | MAPT (0.55) | KIF11CTNNB1WNT3ARAB9AKDM4E | |
| SCHEMBL4404389 | 0.69 | KIF11 (1.00) | KIF11CA2CA1CA9CA12 | |
| SCHEMBL2005036 | 0.69 | CA2 (0.74) | KIF11CA2CA1CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057958-A1 | AMINOTETRALINE AND AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-08-24 | — | — | EP | claimed |
| WO-2015055771-A1 | AMINOTETRALINE AND AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-04-23 | — | — | WO | claimed |