Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499542 | 0.82 | KDM4E (0.64) | GAATDP1L3MBTL1CNR1KDM4E | |
| SCHEMBL9498007 | 0.82 | KDM4E (0.64) | GAATDP1L3MBTL1CNR1KDM4E | |
| SCHEMBL9498652 | 0.82 | KDM4E (0.64) | GAATDP1L3MBTL1CNR1KDM4E | |
| SCHEMBL9497942 | 0.82 | KDM4E (0.64) | GAATDP1L3MBTL1CNR1KDM4E | |
| SCHEMBL17817424 | 0.82 | GAA (0.76) | GAATDP1L3MBTL1KDM4ECYP3A4 | |
| SCHEMBL8708567 | 0.82 | ALDH1A1 (0.69) | GAATDP1L3MBTL1TP53MAPT | |
| SCHEMBL8368156 | 0.82 | GAA (0.76) | GAATDP1L3MBTL1KDM4ECYP3A4 | |
| SCHEMBL10683818 | 0.76 | MAPT (0.59) | GAATDP1L3MBTL1KDM4ETP53 | |
| SCHEMBL374670 | 0.76 | HSD17B1 (0.48) | GAAKDM4ECYP3A4MAPTTSHR | |
| SCHEMBL3976468 | 0.76 | CYP1A1 (0.44) | GAATDP1KDM4ETP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057943-A1 | PYRIMIDINE FGFR4 INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057938-A1 | PYRIMIDINE FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |